The 6 Changes in Lifetime Hormone Levels that Cause Aging – And How to Easily Reverse Them!


After spending 30 years, so far, of studying the aging process from every possible angle, it becomes clearer and clearer to me that aging is not some mysterious, inscrutable, unsolvable problem. Rather, it is quite apparent that aging is controlled, like many other things in our lives, by changes in hormones. Do bear with me and let me give you a little background on aging first, then you will get VERY USEFUL information about the hormone changes that cause it – complete with graphs and charts!

The Background and the Controversy:

The conventional view of aging, which is currently in a state of major change, has been that aging was just an accidental artifact of us and other animals living too long, because we had never lived this long in the past. Since life was nasty brutish and short, we never evolved mechanisms to keep our bodies alive at ages that they never reached in “the wild”. In fact a common quip by aging theorists of the recent past was “animals don’t age in the wild”, said with much confidence and authority. This has proven to be completely untrue.

Truly this was a very simplistic and wrong-headed view as we shall soon see.


aging and evolution


The new thinking that is emerging amongst the younger students of aging and evolution is that aging evolved for a purpose and thus is controlled like many other facets of human life by changes in hormones. If you search the Pub Med Science database for the terms aging and evolution, there almost hasn’t been a paper published in years that did not question the prevailing paradigm of the past and suggest that aging was actually programmed. And what drives our lifetime programs more than anything else? You got it – HORMONES!

There can be no denying that female menopause is driven by dramatic changes in hormone levels.  It is so obvious because it happens so quickly relative to the total human life span.

What was not so obvious until recently is how other hormones vary over the typical human lifetime to drive the aging process. Except for menopause, the changes caused by aging-related hormones occur gradually in humans. A classic example of rapid hormone-driven aging can be seen in the case of the Pacific Salmon who live for 3 years and then return to their spawning grounds to reproduce. And in the 3 days after spawning they deteriorate rapidly and die! Poof! Just like that. And if you castrate them, they can live for 7 years!

The old theory, when confronted with the obviously rapid programmed aging of the Pacific Salmon, simply created a new category of aging called semelparous aging (aging during a one time burst of reproduction) – and with the wave of a hand said it had nothing to do with other types of aging! Out of sight out of mind!


pacific salmon spawning
pacific salmon spawning


pacific salmon dying after spawning
3 days later


For humans, it turns out there are hormones that are good for you and prevent aging. And there are also hormones that are bad for you and promote aging. (The aging-promoting hormones that when increased initially drive the development program and cause the initiation of puberty, are elevated even more at older ages and drive the aging program – it is all one seamless mechanism).

Okay now the stuff you have been waiting for!

Let’s start with the hormones that are good for you first: Melatonin, Pregnenolone, DHEA, and Progesterone.


The master hormone that controls your other reproductive hormones and suppresses the “bad“ hormones. It peaks at night and drops dramatically in the daytime. It is like your hormonal clock. The problem is that when we age the nighttime peaks in melatonin get smaller and smaller. This is the trigger that causes all sorts of other pro-aging hormonal changes to occur.


melatonin graph


I know from personal experience and blood testing that when I take large doses of melatonin it boosts my progesterone levels up quite high, to about 30% higher than the upper limit of the normal reference range for men of my age. I suspect that high melatonin peaks also promote higher levels of DHEA and pregnenolone as well. Progesterone, pregnenolone, and DHEA are all “good hormones” that decline with age.

In a study involving mice and rats, the melatonin levels of these animals shoot way up, way higher than their youthful nighttime peaks when they are semi starved. And what else happens? The mice live up to 40% longer than normally fed mice. Is there a link? I am sure there is. Another hormone that also increases quite a bit during caloric restriction is DHEA. Let’s look at DHEA next.


Caloric Restriction in Mice

caloric restriction in mice


DHEA (dehydroepiandrosterone):

DHEA is a steroid hormone very similar in structure to estrogen and testosterone. There are quite a few books about DHEA as being a wonder anti-aging hormone that prevents cancer and is a potent antioxidant. What happens to your DHEA levels when you age?


Need I say more?



This hormone is known as the super-memory hormone. Giving pregnenolone to old rats boosts their memory to the same level as that of young rats. It is also a steroid hormone. “Steroid” just means it is a hormone that is initially created from cholesterol. So what happens to your pregnenolone levels when you age?




Need I say more?



The first step for all steroid hormone synthesis occurs when the body makes pregnenolone from cholesterol. Step two is when our bodies use some of that pregnenolone to make progesterone. All other downstream steroids like testosterone and estrogen originally start off as progesterone.




All steroids have a very similar chemical structure:




But don’t let that fool you! They may all look the same like magnetic hotel room keys do. But due to their differing electrical signatures they bind to specific hormone receptors and this explains their dramatically different effects while appearing so similar.

Progesterone is known to be one of the most neuroprotective substances known to man, and is known to be the reason why women recover from brain injuries much more easily than men – due to higher female progesterone levels. At menopause, women’s progesterone levels crash to almost 0, while it takes a bit longer for men’s progesterone levels to crash which happen in their 60’s and 70’s.


progesterone levels
Progesterone levels in women by age


Two interesting points to make about progesterone are that one, the negative symptoms of menopause like night sweats, weight gain, and mood changes, are now believed to be caused by the unopposed estrogen which declines at a slower rate than progesterone does in the menopause. Some doctors are now giving their menopausal patients 300 mg of progesterone per day to eliminate these symptoms. Secondly, while researching the cause of ALS for a reader, I noticed that men get the dreaded ALS at a 4 to 1 ratio as compared to women. However, after menopause the ratio becomes 1 to 1. This told me that progesterone might be protective against ALS and indeed a later mouse study by Korean researchers found that progesterone dramatically prolonged the lives of male mice in a mouse model of ALS. Remember – progesterone is the most neuroprotective substance on earth!

The Anti-Aging Solution

It is simple, if you want to slow and even reverse the aging process, you need to supplement with DHEA, pregnenolone, and melatonin, and maybe progesterone. Because increasing your melatonin levels leads to increase in progesterone so you might not need extra progesterone.

All these hormones are available over the counter without a prescription in the US – which is an unusual situation compared to the rest of the world where many hormones are available by prescription only.

If you want to supplement with smaller amounts of progesterone you can also get progesterone cream (which absorbs through your skin) without a prescription in the US as well. High-dose progesterone – brand name Prometrium – is available by prescription only and is dramatically overpriced!

What dosages should you take? That is a good question.

For DHEA, it’s 100 mg for men and maybe 25 to 50 mg a day for women

For melatonin, if you really want the anti-aging effects you will likely want to try higher doses than are considered normal. Like 75 mg a night for women and 120 mg a night for men. Just be prepared for the 4-month adjustment period of lots of sleeping!

For pregnenolone, 100 mg a day is likely fine. I take 200 mg a day and there have been no adverse effects from even 400 mg a day.

I do not take progesterone. My melatonin intake seems to boost it. Melatonin also boosts progesterone levels in females. It is up to you to decide whether to supplement.

So now let’s take a look at the two major hormones that increase dramatically after age 50 in both men and women that are bad for you and drive both the aging process and menopause.

FSH (Follicle Stimulating Hormone) and LH (Luteinizing Hormone):

These two hormones were originally discovered as being major players in women’s monthly reproductive cycles.

FSH stimulates the maturation of the human egg called the ovum. Once the egg has matured, LH increases. One of the functions of the increased LH level is to eat away at the follicle so the egg can be released into the fallopian tube for fertilization by the sperm.

However a funny thing happens after the age of female menopause (around age 50) in both men and women. The FSH and LH levels increase by very large amounts of up to 1,000 percent!

These increases were ignored for years by mainstream scientists, but I proposed in my 1998 paper on aging that these hormones actually drove the aging process. Scientists laughed at my proposed idea but facts have been coming out with a vengeance that this is indeed the case!

It turns out that the NIH, not too long ago, has agreed that LH is intimately involved in driving the attack on the brain that causes Alzheimer’s. It has also been found that men with higher levels of LH showed more signs of frailty.

Recently, FSH has been implicated in causing osteoporosis (as predicted in my 1998 paper) as well as age-related weight gain. I expect FSH will also be found to be the cause of the destruction of both heads of the femur that is causing us all to get knee and hip replacements in alarming numbers!

Take a look at the lifetime female LH and FSH levels:

(Men show a similar pattern after the age of 50 except with a relatively larger increase of FSH to LH as compared to females).


FSH and LH


So how do you keep these “bad” hormones from increasing?

Thankfully, it is very simple – just take high doses of melatonin. Melatonin suppresses both FSH and LH.

Melatonin suppression of FSH and LH explains why melatonin taken early on in the initial stages of menopause REVERSES menopause and reinitiates the menstrual cycle!

There are a few hormones I did not address like the dramatic decline in Growth Hormone with age. It has been found that mice deficient in growth hormone live much longer than controls, and that GH supplementation can make you look better but does not make you live longer and might even give you diabetes.

So that’s it for this summary! If you would like to know more about hormone changes and aging you can get a much more detailed look at this in my book “What Darwin Could Not See – The Missing Half of the Theory” available  at

And finally, if you plan on performing your own high dose melatonin, pregnenolone, resveratrol, DHEA, or Vitamin D3/Vitamin K2 experiment  to prevent aging or to treat various chronic medical conditions. You might want to consider buying bulk powder vitamins/hormones  rather than pills given the high doses involved  and the high cost of pills. For example Vitamin K2  can cost  $6,500 per gram if you buy Dr. Mercola’s pills, 30X the cost of gold!! If you buy pure bulk K2 powder  you can get it for just $15 per gram. It’s not just BigPharma who is ripping us off! Find out more from this article>>>>


How to Save 90%+ on Vitamins, Hormones:BUY Bulk Powder-Vit K2 Can Cost 30X More Than Gold!




About the Author

In 2010, Jeff T. Bowles began a series of e-book bestsellers to publish health issues that deal with the problem of healing and aging from an evolutionary perspective. By joining the simple logic of evolution with a large number of diverse facts as well as the results of his 25-year-old private research, Jeff was able to demonstrate a wide range of new, simple, and very effective ways to relieve many chronic diseases, such as multiple sclerosis, asthma or age-related diseases such as Alzheimer’s and ALS. Jeff was the first person who could show in a rat experiment (1997-2001) that rats whose water intake is restricted, live significantly longer (even longer than restricting food). In 1998 his article “The Evolution of Aging – A New Approach to an Old Problem of Biology” was published in the journal Medical Hypotheses. Later he published two other articles in the journal. His hypothesis that the suppression of a certain hormone can stop the progression of Alzheimer’s disease resulted in the founding of the company Voyager Pharmaceuticals, which showed in a 50-million dollar project, that the suppression of the hormone LH in women actually prevented the progression of Alzheimer’s disease. In his proto-book about ALS he predicted in January of 2013 that progesterone would be the first effective treatment for ALS ever. Six months later some Korean researchers showed that progesterone dramatically extended the lives of male mice in a mouse model of ALS – the equivalent of 17 human years whereas most ALS patients only survive 2 to 4 years.




27 thoughts on “The 6 Changes in Lifetime Hormone Levels that Cause Aging – And How to Easily Reverse Them!”

  1. Have you speculated on the underlying reason for these changes in hormone levels? I mean, biologically what is changing to drive this?

  2. You would think high LH and FSH levels in males would be a good thing. Doesn’t LH signal the testicles to produce testestosterone and other hormones?

    1. HI there

      I recently saw a testimonial from a mother about heself and her son, that both had snoring problems…but they noticed that it went away but it took 2 years of high dose vitamin d3 to fix it. I think I should collect data on this give it a shot!!

  3. Jeff if Melatonin is the master hormone that drives the levels of the others, would simply taking high dose melatonin, lead to stable high levels of pregnenolene, progesterone, DHEA etc.

    1. HI there
      Yes it might be ok to just take melatonin, as long as your steroid pathways remain intact….
      But I have heard of a study where they supplemented all the downstream steroid hormones from cholesterol which led to a reduction in cholesteol levels.
      The thinking was that when there is a call for a certain hormone but the conversion pathways were starting to malfunction (mabye due to reduced levels of converting enzymes)
      then the body just keeps calling for more cholesterol to start the process of creating the hormone… (the upstream precursor to all the steroid hormones..)
      so this line of thinking suggests as we age our steroid synthesis pathways start to break down…So if this is true…then it is smart to take the extra dhea and pregnenolone and progesterone
      I guess it would be easy to test….You could order the blood test from before you start your melatonin …measure pregnenolone, dhea and progesterone and other LH and FSH ..then take your melatonin for a month and retest…..Then you will find out..then let me know!! Thanks

  4. Just found this abstract>>>
    Int J Oncol. 2017 Jan;50(1):317-328. doi: 10.3892/ijo.2016.3787. Epub 2016 Dec 2.
    Pituitary sex hormones enhance the pro‑metastatic potential of human lung cancer cells by downregulating the intracellular expression of heme oxygenase‑1.
    Abdelbaset-Ismail A1, Pedziwiatr D1, Schneider G1, Niklinski J2, Charkiewicz R2, Moniuszko M3, Kucia M1, Ratajczak MZ1.
    Author information
    We report that human lung cancer cell lines express functional receptors for pituitary sex hormones (SexHs) and respond to stimulation by follicle‑stimulating hormone (FSH), luteinizing hormone (LH), and prolactin (PRL). Expression of these receptors has also been confirmed in patient lung cancer samples at the mRNA level. Stimulation of human lung cancer cell lines with FSH, LH, or PRL stimulated migration and chemotaxis, and some cell lines responded by enhanced proliferation. Moreover, priming of human lung cancer cells by exposing them to pituitary SexHs resulted in enhanced seeding efficiency of injected human lung cancer cells into bone marrow, liver, and lungs in an immunodeficient mouse model. The chemotaxis of lung cancer cell lines corresponded with the activity of heme oxygenase‑1 (HO‑1), as stimulation of these cells by FSH, LH, and PRL downregulated its expression in a p38 MAPK‑dependent manner. Moreover, while downregulation of HO‑1 by the small‑molecule inhibitor tin protoporphyrin (SnPP) promoted migration, upregulation of HO‑1 by the small‑molecule activator cobalt protoporphyrin (CoPP) showed the opposite effect. Based on this finding, we propose that pituitary SexHs play a significant role in the pathogenesis of lung cancer, particularly when the blood level of FSH increases due to gonadal dysfunction with advanced age. Finally, we propose that upregulation of HO‑1 expression by a small‑molecule activator may be effective in controlling SexH‑induced cell migration in lung cancer.

  5. Hi Jeff,
    Have you researched and published about oxytocin, endorphin, dopamine, serotonin, thyroidal hormones and hypothalamus and it’s role in aging?

    1. Hi Ashkay

      I have been looking into oxytocin and take it from time to time

      there are suggestions that is might slow sarcopenia (muscle wasting with age) but then three is a study in worms that the worms lacking oxytocin lived longer and were more stress resitant. this is a good area for research ..
      What I alays look for are studies tha measure changes in hormones with age….and I focus on those that increase quite a bit or decline….And I dont remember seeing thyroid horkones changing much with age…As far a oxytocin goes…it seems to be quite high in childhood and to age 20 but then flat lines for the most part for the rest of the lifespan

      see this link>>

      have you come up with anything??

  6. Oxytocin seems to decline with age. Berkeley researchers
    I think Villeda said fasting over 7 days generates an oxytocin bath that rejuvenates stem cells amongst many other benefits. And Irina Conboy’s study in Nature
    Singling out oxytocin as one of the factors that keep us young. You have read all of this as you research extensively. The data you cite that supports your vitamin D and hormone theory of aging is absolutely compelling. So other hormones too decline not too precipitously as some. If you deep dive into any other hormone besides the ones you have already studied I would very keen to read that 🙂

    1. HI there thanks….
      I do sniff oxytocin spray from time to time you can get a big bottle cheap from Khemcorp..they sell mainly to autistic people…ONe additionl a hormone that declines with age that I might havre left off is ACTVE Vitamin D3….possibly we need to take the active form (prescription only) called calitriol as opposed to the cholcalciferol ( d3) that they sell over the counter….Because your body’s ability to convert cholecalciferol to calcitriol in the kidneys appears to decline as we age….although I do hear from people in their 70’s that high dose d3 still has curative powers…for at least crohn’s depression and atrhritis.and others .also some people who do not respond to vitamin d3 might want to try prescription calcitriol (as they might have some sort of problem converting D3 to the active form calcitriol)

    1. HI there I have never used it or looked into it it much but it appears at first glance that you take the same amount as if it were vitamin d3
      as they normal daily dose they prescribe is 1,000 IUs. I tis used mainly by people who have liver or kidney prblems who canot covert enough D3 to
      calcitriol..For some reason it is a prescription medicine!! But do not ely on this cometn if you are goig to take it
      do some research yourself thanks..

  7. Great article! I heard that high melatonin dosages kill sex drive. Any ideas on how to fix that?

    1. Hello Neil,

      Yes sorry to say that in additiomn to growing a man’s hair back high dose melatonin can have the side effect of reducing sex drive. Melatonin seesm to be evoluton’s famine hormone so when you are starving it goes way up and keeps your mind off of wasting energy on sex so you can survive the famine..It also acts as birth control in women. But the good news is that after about 4 months or so the anti sex effect seems to wear off. Also you might be able to take vitamin d3 with the melatonin and D3 seems to counteract some aspects of the melatonin effects, like you don’t need as muich sleep if you take d3 and melatonin together asopposed to just melatonin. You can think of melatonin as the winter /famine hormone and d3 as the summer abundance hormone….If you wer to take the drug propecia for hair loss it can have the same sexual side effects beasue propecia is just an altered version of progesteone that they cold patent. melatonin works to grow hair by boostign a man’s progesterone levels and progesterone prevents testosterone from bneing converted into the sex drive bosoitng and hair losing version of testosterone known as DHT.

  8. How does the dose of DHEA change for someone with G6PD deficiency (DHEA is said to lead to RBC death in such people)?

    Why is so much required when 2-4 mg is the replacement dose for a 50 year old male?

  9. For someone female with mild Alzheimers/dementia wanting to increase progesterone (for neuroprotective effects)

    Should they directly take progesterone pills (available via script)?

    Or should they increase progesterone indirectly via pregnenolone or melatonin?

    1. HI there… that is a good question and it probably hasn’t been studied yet.
      If it were me I would probably try to get prometrium pills (progesterone) if the doc would give me a scrip
      and maybe try 50 mg a day , and additonally take melatonin 100 mg at night . It would be an experiment ..

  10. Do you have a comment or suggestions about taking ESTROGEN for older male in order to extend life span? You said Estrogen hormone is one of the reasons female live longer than male.
    Thank you. Kay

    1. HI there

      I don’t remmeber saying that estrogen is one of the reasons females live longer than males and estrogen increases in many males with age and has been linked ot increased risk of prostate cnacer..ONe thing that probably would help males live longer is to give them progesterone cream starting in tgheir 60’s

  11. You also mention cycloastragenol, ta65, in one of your books, and you propose astragalus root as a cheap alternative, but it contains small quantities, I am afraid it cannot reach the quantities delivered by the supplement.
    There are also astragalosides in astragalus.
    It is claimed that Cycloastragenol extends chromosomes. What hormones/ small molecules would you recommend instead to get the same action? Ta65 is the most expensive supplement right now.
    Also, can you suggest other cheap alternatives to expensive nmn? For example, niacine is close enough, and I wonder if it can completely elt substitute for pricey nmn.

    1. HI there I have not studied the question of trying to extend your telomeres very deeply
      I do know that vitmain d3 has been associated with longer telomeres..I think the #1 most effective anti aging supplememt
      will likely be found to be high dose melatonin right before bed…Also the #1 anti aging herb in Chinese medicine is Fo Ti root
      which is structureally similar to resveratrrol but has some extra things attcahed to it/
      Some people claiom it turns their gray hair black or whatever color it was before..

  12. Hi Jeff!

    Fascinating theory on aging that makes a lot of sense!

    My question regarding high dosage melatonin for a longer time: Does this shut down the body’s natural melatonin production?

    Sort of like taking testosterone for longer periods might shut down your natural testosterone production.

    In other words, do you become dependent on otc melatonin over time? I’m still quite young (33y) so would it be a good idea to start taking big doses of melatonin? I now ocassionally use about 2-4mg per night when I want a good nights sleep.

    1. HI there Mathias

      I wouldn’t worry about shutting down your body’s ability to make melatonin because by age 60 or 70 you pretty much don’t make any anyway

      also when one is starving the melatonin levels go way higher than normaland trigger the aging reversal/slowing process

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