Like a secret alchemist toiling at odd hours, not wanting to be seen, trying to transform common ordinary substances into gold with the philosopher’s stone, I have been experimenting with very high doses of melatonin on myself and others, off and on, for over 20 years. I have discovered some truly amazing things about it. But first let’s get a little background information.
Melatonin is a hormone made by a small gland in your brain that looks like a pine cone called the pineal gland. It is pretty small as far as hormones go, but in fact it is probably the most important hormone of them all and basically controls almost every aspect of your life from childhood development to reproduction to menopause to aging and even death!
I have learned over the years that high doses of melatonin can be used to produce various dramatic results.
Did you know that:
-High doses of melatonin (75 mg/night) can and has been used as an effective and heathy form of birth control?
-High doses of melatonin will regrow a man’s thinning hair as effectively as propecia or even better?
-Melatonin has been shown to halt and even reverse Alzheimer’s disease in various small studies.
-Melatonin has been used to REVERSE menopause in women undergoing recent menopause.
-The decline in melatonin levels in women in their early 50’s is the hormonal trigger that initiates menopause.
-High-dose melatonin can be used to eliminate a woman’s menstruation for prolonged periods in a healthy manner.
-It is very likely that high-dose melatonin can be used for birth control in a manner similar to the morning after pill.
-Melatonin levels increase dramatically when an individual is undergoing semi-starvation or prolonged fasting. This is interesting in that when lab animals undergo semi-starvation for prolonged periods they can live up to 40% longer than controls.
-Adding melatonin to the night time drinking water of mice makes them live 20% longer!
-Giving high-dose melatonin to children will prevent early onset of puberty.
-Melatonin is not just a hormone; it is a powerful antioxidant that can cross the blood-brain barrier.
-I personally have learned that taking high doses of melatonin every night (up to 500mg), will, within a few days to a week, require your body to sleep 12 hours per night and take additional naps during the day. You can even fall asleep sitting up in a moving car! Eventually after about 3 to 4 months, the need for sleep diminishes, and you can still take high doses of melatonin and get by with maybe just 7 hours per night of sleep.
-Chronic interference with melatonin by either sleep deprivation or exposure to bright light during sleep can lead to a significant increase in the risk of breast cancer and prostate cancer.
-High-dose melatonin can lead to dramatic drop in blood pressure, in just a few days, as much as a 50-point drop on both diastolic and systolic scales.
You can get much more detailed and unusual information about Melatonin from my new book available on Amazon titled:
Extreme Dose! Melatonin The Miracle Anti-Aging Hormone Anti-Alzheimer’s Hormone Anti-Baldness Hormone Menopause Reversal Hormone
Which sources of food have melatonin
I just googled food sources of melatonin>>
Some foods naturally contain melatonin and are therefore great to have at an evening meal or as a light night time snack:
Bananas.
Morello cherries.
Porridge oats.
Sweet corn.
Rice.
Ginger.
Barley.
Tomatoes.
Int J Oncol. 2017 Jan;50(1):317-328. doi: 10.3892/ijo.2016.3787. Epub 2016 Dec 2.
Pituitary sex hormones enhance the pro‑metastatic potential of human lung cancer cells by downregulating the intracellular expression of heme oxygenase‑1.
Abdelbaset-Ismail A1, Pedziwiatr D1, Schneider G1, Niklinski J2, Charkiewicz R2, Moniuszko M3, Kucia M1, Ratajczak MZ1.
Author information
Abstract
We report that human lung cancer cell lines express functional receptors for pituitary sex hormones (SexHs) and respond to stimulation by follicle‑stimulating hormone (FSH), luteinizing hormone (LH), and prolactin (PRL). Expression of these receptors has also been confirmed in patient lung cancer samples at the mRNA level. Stimulation of human lung cancer cell lines with FSH, LH, or PRL stimulated migration and chemotaxis, and some cell lines responded by enhanced proliferation. Moreover, priming of human lung cancer cells by exposing them to pituitary SexHs resulted in enhanced seeding efficiency of injected human lung cancer cells into bone marrow, liver, and lungs in an immunodeficient mouse model. The chemotaxis of lung cancer cell lines corresponded with the activity of heme oxygenase‑1 (HO‑1), as stimulation of these cells by FSH, LH, and PRL downregulated its expression in a p38 MAPK‑dependent manner. Moreover, while downregulation of HO‑1 by the small‑molecule inhibitor tin protoporphyrin (SnPP) promoted migration, upregulation of HO‑1 by the small‑molecule activator cobalt protoporphyrin (CoPP) showed the opposite effect. Based on this finding, we propose that pituitary SexHs play a significant role in the pathogenesis of lung cancer, particularly when the blood level of FSH increases due to gonadal dysfunction with advanced age. Finally, we propose that upregulation of HO‑1 expression by a small‑molecule activator may be effective in controlling SexH‑induced cell migration in lung cancer.
Just found thisw abstract which suggests melatonin should be good for preventing the spread of cancer cells because it suppresses LH and FSH>>>
Int J Oncol. 2017 Jan;50(1):317-328. doi: 10.3892/ijo.2016.3787. Epub 2016 Dec 2.
Pituitary sex hormones enhance the pro‑metastatic potential of human lung cancer cells by downregulating the intracellular expression of heme oxygenase‑1.
Abdelbaset-Ismail A1, Pedziwiatr D1, Schneider G1, Niklinski J2, Charkiewicz R2, Moniuszko M3, Kucia M1, Ratajczak MZ1.
Author information
Abstract
We report that human lung cancer cell lines express functional receptors for pituitary sex hormones (SexHs) and respond to stimulation by follicle‑stimulating hormone (FSH), luteinizing hormone (LH), and prolactin (PRL). Expression of these receptors has also been confirmed in patient lung cancer samples at the mRNA level. Stimulation of human lung cancer cell lines with FSH, LH, or PRL stimulated migration and chemotaxis, and some cell lines responded by enhanced proliferation. Moreover, priming of human lung cancer cells by exposing them to pituitary SexHs resulted in enhanced seeding efficiency of injected human lung cancer cells into bone marrow, liver, and lungs in an immunodeficient mouse model. The chemotaxis of lung cancer cell lines corresponded with the activity of heme oxygenase‑1 (HO‑1), as stimulation of these cells by FSH, LH, and PRL downregulated its expression in a p38 MAPK‑dependent manner. Moreover, while downregulation of HO‑1 by the small‑molecule inhibitor tin protoporphyrin (SnPP) promoted migration, upregulation of HO‑1 by the small‑molecule activator cobalt protoporphyrin (CoPP) showed the opposite effect. Based on this finding, we propose that pituitary SexHs play a significant role in the pathogenesis of lung cancer, particularly when the blood level of FSH increases due to gonadal dysfunction with advanced age. Finally, we propose that upregulation of HO‑1 expression by a small‑molecule activator may be effective in controlling SexH‑induced cell migration in lung cancer.
I’m curious. In Jeff’s book about melatonin, it says “Thus, taking melatonin and D3 together might actually counteract the healing properties of D3 taken alone”.
Is that saying that while taking mega doses of D3 one should not take any supplemental melatonin if one wants to get the most from vitamin d supplementation?
Hello there-thanks for writing
I am not sure about this…It might be true….One thing I noticed about taking high doses of d3, at lower doses m maybe 50,000 a day it gives me a lot more energy, but if I took a whole lot
(75,000+) it would make me sleep longer like I had been in the sun all day
and then when I added high dose melatonin it seemed to counteract this sleep effect of D3…and I did’t get the large sleep inducing effect of melatonin at the same time either
I expect High dose melatonin would trick your body into thinking it was starving, as it increases during fasting.. and triggers the anti-aging effect. high dose D3 would trick your body into thinking it was
the middle of summer and lots of resources might be available. If you are taking high dose D3 to fix something I would suggest you might not take really high doses of d3 for the first three months or so
Once you have fixed your problems then one could take high dose melstonn for its antiaging effects…This is my speculation n the subject.
Why would a stack combining 60,000 IU D3, 1.4 grams magnesium, 15 mg MK-4, and 240 mcg MK-7 ruin sleep? I haven’t been sleeping well for many years now. I took a bit of melatonin (1 mg) and it further showed I wasn’t sleeping well, but it didn’t work well enough. I consistently and easily drift off to sleep, but wake up frequently throughout the night and awaken early (after ~6 hours).
Hello there
insomnia is often a symptom of magnesium deficiency…. High dose vitamin d3 causes your body to use up magnesium at a very high rate.
80% of us are magnesoum deficient due to soil depletion..I would suggest stopping the d3 for awhile…and taking magnesium sevgeral times througout the day you want int your blood at all times if possible. You might sant to try an extended release magnesium from http://www.lef.org take 3x a day….It si very hard to reverse a magnesium deficiency can take a year or more…
This could very well be cortisol & adrenaline waking you. Chamomile is anti-cortisol, so taken at bedtime and again upon first wake-up helps. Excess magnesium holds potassium in the cells (which can cause pain), & also too-high potassium can cause cortisol to rise too much & at the wrong time [= insomnia]. Also, the lack of proper natural light all day can disrupt the important circadian rhythm/sleep-wake cycle.
Too, many ppl are having trouble with an (excitatory-)glutamine-(calming-)GABA imbalance. There is a marvelous GABA product (‘Gabatrol Stress & Mood,’ by Purelife) that has co-factors with the GABA that DOES get the calming GABA through the blood-brain barrier & into the brain, giving a good night’s sleep.
Does melatonin result in regrowth of a receding hairline or is it just preventing recession?
What do you mean by “anti-baldness hormone”?
What dose is required for this effect and with what cycle (ie, how many weeks on and how many weeks off before starting again)?
What positive and what negative effects did you experience?
hi there in my case I didnt hae muhc of a receding hairline so I dont know about that..but it did make the hair on the top of my head grow in thick after it had thinned out quite a bit….It took a bout 4 mon ths of me taking high dose melatonin around 100 mg a night or so..It does have sexual side effects at first for a few months simialr to propecia but they clear up after 3-4 months I write a book on melatonin if you want the big long story
How do you take the bulk melatonin powder?
Do you put some under the tongue for sublingual absorption?
Or drink it dissolved in water?
HI I personally put it under my tongue at night
I have been reading about higher dose melatonin interfering with bone metabolism & possible increases in osteoporosis. Your thoughts on this?
Where have you been readig about this….do you have any source material? when I google melatonin and bone metabolsim I get a lot of things liek this poppiung up>>>
Melatonin Effects on Hard Tissues: Bone and Tooth – NCBI – NIHhttps://www.ncbi.nlm.nih.gov › articles › PMC3676828
by J Liu · 2013 · Cited by 68 — [67] found that after five- and eight-week treatment periods, melatonin significantly increased the inter-thread bone and new bone formation in …
Bone and Tooth · Melatonin and Bone · Melatonin and Tooth · Conclusions
Melatonin levels have been correlated with modulating bone markers; low nocturnal levels of melatonin correlate with in an increase in bone marker metabolism and osteoporosis. It is been shown that women who have worked night-shifts for greater than 20 years have increased risk for wrist and hip fractures.