This report examines the hypothesis that the convergence of increased childhood aluminum exposure through expanded vaccination schedules, rising magnesium deficiency, and declining vitamin D3 synthesis due to reduced sun exposure has created optimal conditions for the dramatic rise in autism spectrum disorder (ASD) diagnoses since the 1980s. Drawing from insights gained in amyotrophic lateral sclerosis (ALS) research showing that elevated aluminum-to-magnesium ratios contribute to neurodegeneration, we propose a similar mechanism may operate in autism pathogenesis. This analysis synthesizes epidemiological data on vaccine schedules, aluminum exposure patterns, outdoor activity trends, and autism prevalence to evaluate this multi-factorial hypothesis.